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Emphasizing imaging alone without therapy functionality won't be the main point of the report, and such discussions can be found in many exceptional reviews. 2,3 As an alternative, the development and design of theranostic agencies, especially from the chemistry perspective, and possible Cilengitide applications will be discussed and addressed herein. Gold based nanomaterials Due to their more developed strategies and superior bio-compatibility for surface modification, gold based nanomaterials have been examined as multi-functional probes. The initial optical and photothermal faculties of gold nanomaterials enable them not only to be employed as sensing tools but additionally to induce photothermal consequences for therapeutic purposes. The localized surface plasmon resonance of gold nanomaterials can be adjusted by tuning their morphology; gold nanoshell, NP, nanorod, and nanocage show distinctive optical and thermal Eumycetoma properties, which can easily upgrade gold nanomaterials to be prospective theranostic agents. Gold nanomaterial offers a versatile program for simultaneously carrying therapeutics and diagnostics on its floor via gold thiol bonding. Subsequently, those connected drugs might be intracellularly released from gold nanocarriers by exchange reactions with cytosolic glutathione. 4 In a recent report described by Heo et al5 AuNP modified with multiple ligands, including PEG, biotin, paclitaxel, and rhodamine B associated B cyclodextrin on the top was proven to be a helpful theranostic agent for cancer therapy without a cytotoxic effect on normal cells. Being an optical imaging agent lacking implicit fluorescent attributes, regular sized AuNP was rarely used. But, 2-ME2 due to its higher atomic number and X-ray absorption coefficient than iodine, the feasibility of AuNP as contrast agent in computed tomography imaging was analyzed. 6 In addition, Kim et al introduced fresh multifunctional AuNP for focused molecular CT imaging and treatment of prostate cancer,7 when a prostate specific membrane antigen RNA aptamer that bound to PSMA was functionalized onto the surface of AuNP. It was confirmed in the research that the as made PSMA aptamer conjugated AuNP exhibited higher CT strength toward focused LNCaP cells than that of nontargeted PC3 cells. Moreover, PSMA aptamer conjugated AuNP packed with the anticancer drug doxorubicin was somewhat more effective against precise LNCaP than against nontargeted PC3 cells. Furthermore, the large X-ray absorption coefficient makes silver nanomaterial not just a great CT imaging contrast agent but also a fantastic radiotherapy sensitizer. As we know, the biggest problem for radiation therapy would be to achieve the best probability of cure without significant morbidity. Targeted delivery of radiotherapy sensitizer to the tumor site appears to increase the precision of radiation treatment, in order that more targeted doses could be provided while reducing the impact on neighboring tissues.